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Mysige Nani (Caribacka's Nani) är november månads katt
Ägare är Sansan Nilsson
A new coat color termed “Russet” has been identified in Burmese cats with Australian and New Zealand lineages.The russet phenotype develops with age. Young russet kittens have color and markings largely identical to tabby kittens of the same age and base color, regardless of whether the kitten is agouti (A-) or non-agouti (aa) in genotype. However, the tail-tip, genital area, and fur around the paw pads are pale in russets rather than marked with dense eumelanin as in tabbies. The nose leather is entirely pink rather than outlined in eumelanin, and the paw pads are pale, later losing all melanin to become bright pink. As the kitten grows, the solid eumelanin areas are progressively overlain with presumably phaeomelanin (red pigment), starting at the head, which usually turns entirely red. On the dorsal surfaces, broad tipping of the fur with pheaomelanin develops gradually. There is also some reduction in density of melanin in the bottom half of the hair nearest the skin. The mature cat is superficially reddish all over, but with the eumelanin pigment in the dorsal undercoat visible to an extent that varies between individuals. The mutation responsible for Russet color was identified by Dr. Leslie Lyons and her research group at the University of Missouri. Russet is an autosomal recessive trait which means that two copies of the russet allele are needed to produce the phenotype.
The VGL has developed a genetic test for Russet in Burmese and related breeds. Cats of questionable coloration, including those considered to be Dilute Modifier, should test for russet prior to considering the cat as having Dilute Modifier.
Results reported as:
N/N: No copies of the Russet mutation
N/R: 1 copy of the Russet mutation
R/R: 2 copies of the Russet mutation. Cat is or will turn Russet in color when mature
We have an interest in hereditary skin diseases and I currently have an active research project, during which we investigate cats with FCA. If at all possible, I would like to ask for the following:
· EDTA blood sample (1-2 ml)
· Skin sample in formalin (ca. 5 mm x 5 mm)
· If the vet has access to RNAlater, then please also another skin sample in RNAlater.
· Copy of the pedigree
· Photo(s) of your cat
· Filled and signed submission form
Our submission form including the shipping address can be found here:
You may ship these samples at room temperature and it is sufficient, if they reach us within 5 days after sample taking. There are no restrictions for the import of cat material from the EU into Switzerland. However, I still recommend to send the samples as a regular letter (if the vet has packaging material that is small enough to do so), rather than a parcel. Regular letters are cheap to send and they normally reach us without any problems from all over Europe.
We ask for the skin samples only, if they are readily available during any surgery. If there should be any difficulties in getting skin samples, we can also work with just the blood sample. We will use the EDTA blood to isolate genomic DNA and search for a potential genetic defect. The formalin-fixed skin sample would go to Prof. Dr. Monika Welle who is a veterinary pathologist specializing in skin diseases.
Would you happen to have any non-affected relatives of the cat with cutaneous asthenia? If you have access to any first-degree relatives (parents, full-sibs, half-sibs), it would greatly help, if we can also get EDTA blood samples from these cats. We don’t need any skin samples from the non-affected cats.
Please feel free to contact me or my PhD student Anina Bauer, if you have any additional questions.
Prof. Dr. Tosso Leeb
Institute of Genetics
University of Bern
Bremgartenstrasse 109a, P.O. Box 3350
Phone +41 31 631-2326
Fax +41 31 631-2640